Cyanamide as a prebiotic phosphate activating agent – catalysis by simple 2-oxoacid salts† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc07517k

نویسندگان

  • Maria Tsanakopoulou
  • John D Sutherland
چکیده

Cyanamide is a prebiotically plausible compound that has previously been invoked as a phosphate activating agent. However, its reactions with phosphate monoesters are very slow and tend to be low yielding. We now report a fast and efficient phosphate activation reaction using cyanamide in the presence of glyoxylate or pyruvate. These simple 2-oxoacid salts are shown to function as catalysts and in an optimised system, adenosine-3'-phosphate was converted to adenosine-2',3'-cyclic phosphate in 95% yield.

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منابع مشابه

A dual catalytic strategy for carbon–phosphorus cross-coupling via gold and photoredox catalysis† †Electronic supplementary information (ESI) available: Materials, full experimental details and characterisation. See DOI: 10.1039/c4sc03092c

A new method for the P-arylation of aryldiazonium salts with H-phosphonates via dual gold and photoredox catalysis is described. The reaction proceeds smoothly at room temperature in the absence of base and/or additives, and offers an efficient approach to arylphosphonates. The reaction is proposed to proceed through a photoredox-promoted generation of an electrophilic arylgold(III) intermediat...

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عنوان ژورنال:

دوره 53  شماره 

صفحات  -

تاریخ انتشار 2017